Based upon a 'human-centred approach', combinations of existing and new methodologies were applied to determine how Ankara's morphological characteristics influenced the magnitude/frequency of Cold Stress (CS) and Heat Stress (HS) to detect/quantify seasonal and yearly human thermal stress frequency. To quantify these conditions upon the human biometeorological system, the Physiologically Equivalent Temperature (PET) was utilised by processing climatic variables from Ankara's Meteorological Station (AMS). In situ assessments of human thermophysiological thresholds were undertaken within characteristic existing/future Urban Canyon Cases (UCCs), with a further stipulation of three interior Reference Points (RPs). Indoor PET values were moreover calculated within a stereotypical vulnerable residential dwelling. Seasonal frequencies revealed that winter PET values frequently ranged between 0.0 and - 19.9 degrees C, with corresponding summer values frequently ranging between 35.1 and 46.0 degrees C. Accounting for Ankara's urban morphology, yearly frequency of No Thermal Stress remained at similar to 48%, CS remained at similar to 26%, and HS similar to 28%. HS varied the most between the eight evaluated Aspect Ratios (ARs). It reduced by up to 7.1% (114 min) within the Centre (RPC) area of UCCs with an orientation of 90 degrees. Out of twelve orientations, the highest HS frequency took place between 105 and 135 degrees Including in UCC3.50, the frequency of HS almost always remained above 72% (2592 min).