It is now widely acknowledged that climate change will have a considerable impact on various aspects of human existence, and this includes happiness and satisfaction with life. This study adds to the existing literature on the contribution of climate to well-being by exploring the interaction of various climate variables at the national and local levels while controlling for socioeconomic factors. Using climate data covering a 20-yr period and demographic data from the Household Income Labor Dynamics in Australia surveys, several ordinary least squares (OLS) models of interaction are developed to test the proposition that climate does influence life satisfaction. Geographically weighted regression is then applied to explore how the relationship between explanatory variables and life satisfaction varies across different regions of Australia. We find that overall rainfall, temperature, and sunshine have a small but significant effect on individual life satisfaction. The spatial analysis reveals a high level of nonstationarity in the way climate variables impact life satisfaction, suggesting that regional climate type may be an important element influencing the relationship. The understanding of this relationship may assist policy makers who develop resilience and adaptation strategies as we face the impacts of climate change.