A regional vulnerability study in relation to the projected patterns of climate change (A2 and B2 scenarios) was developed for the Brazilian Northeastern region. An aggregated Vulnerability Index was constructed for each of the nine States of the region, based on the following information: population projections; climate-induced migration scenarios; disease trends; desertification rates; economic projections (GDP and employment) and projections for health care costs. The results obtained shall subsidize public policies for the protection of the human population from the projected impacts of regional changes in climate patterns.