Introduction: Acute Respiratory Infection (ARI) were still a major problem in Indonesia. Global climate change, especially temperature, humidity, rainfall, disaster haze due to forest fires, the exhaust gas means transportation and air pollution in the home was a double burden of disease in the eradication of ARI. Palembang was the city in South Sumatra are experiencing an increasing number of patients with ARI at the time. Method: This study has been done in September 2014-September 2015. Cross sectional design was used in this study. Result: Correlation test results by using test persons correlation between climate (temperature, humidity, wind speed, and duration of irradiation) the number of ARI cases showed that the variable wind speed has a value of r = 0.608 and p = 0.036, which means that there is a significant correlation between wind speed with the number of cases of ARI and direction of correlation showed a positive correlation direction which has a strong power of influence. Which shows that the higher the wind speed the higher the ARI case. Mapping of the overlay wind speed with the distribution of ARI cases in Palembang 2014 showed that the distribution of ARI cases with wind speeds still clustered in the downtown area and high mobility, among other districts Ilir Timur II, Kemuning, Seberang Ulu I, Ilir Barat I, Sukarami, Kalidoni, Ilir Timur I. A geographical information system ARI can be used to support decision making in knowing the condition last risk populations of ARI and infected trends. In the end result of this mapping will be a contribution to thinking in policy-makers in the field of Communicable Disease Control for the government of South Sumatra Province, particularly the Health Department of Palembang city. Conclusion: So that awareness of the negative impacts of climate change can be minimized. Thus, the increase in the degree of public health can be realized as high as for the efforts undertaken by all components of the nation.