The impacts of global warming and climate change are becoming increasingly severe worldwide and associated coastal flooding is damaging infrastructure and causing human casualties. In this study, we simulated the impacts of sea level rise and storm surge obtained from geographic and past typhoon data (obtained from the National Geographic Information Institute and the Meteorological Administration and National Oceanographic Research Institute) to predict flooding in Yeosu, Korea. Digital surface models were generated from airborne laser scanning to accurately simulate the effect of flooding, and we identified areas and infrastructure at high risk from future flood damage using the predicted significant wave height rise and a region-growing algorithm. Finally, the need to develop a regional disaster plan in response to climate change is proposed.