Many northern Canadians have continued a subsistence lifestyle of wildlife harvesting and, therefore, value sustainable wildlife populations. At a regional wildlife workshop in the Sahtu Settlement Area, Northwest Territories in 2002, elders and community leaders raised concerns regarding wildlife health, food safety, and the effects of climate change on wildlife. They requested that efforts be put toward training youth in science and increasing involvement of hunters and youth in wildlife research. In response, we initiated a long-term, integrated approach to foster community-based wildlife health monitoring and research. Annual trips were made to all schools in the Sahtu from 2003 to 2009 to provide hands-on learning for 250-460 students on a range of wildlife topics. In addition, interviews were conducted with 31 hunters and elders to document their local ecological knowledge of wildlife health and local hunters were trained as monitors to collect tissue samples and measurements to assess body condition and monitor health of harvested caribou (n Euro Surveillance (Bulletin Europeen Sur Les Maladies Transmissibles; European Communicable Disease Bulletin) 69) and moose (n Euro Surveillance (Bulletin Europeen Sur Les Maladies Transmissibles; European Communicable Disease Bulletin) 19). In 2007 the program was extended to include participation in the annual caribou hunt held by one community. Each year since 2005, a graduate student and/or a postdoctoral trainee in the veterinary or biological sciences has participated in the program. The program has evolved during the last 6 years in response to community and school input, results of empirical research, hunter feedback, local knowledge, and logistical constraints. The continuity of the program is attributed to the energetic collaboration among diverse partners and a unified approach that responds to identified needs.