Climate change and human health are intricately linked. The impact on children's health is particularly enormous because of the uniqueness of their bodies' physiology and dependence on adults for protection. This study determined the perception of women about the impact of climate change on health status of their children and analyse the factors influencing children's medical bills. Data were collected with the use of simple random sampling and analysis was done using descriptive and Tobit regression methods. Results show that 49.45% of the children normally fall ill once in at least 4 months while 31.87 were falling sick at least one time in 3 months. Skin infection is the common health problems among children during dry season, which catarrh was most reported (71.43%) during wet season. Tobit regression results show that age (-ve), household size (+ve), per capita expenditure on food (+ve), per capita other expenditure (-ve), falling sick often (+ve), wet season sickness (+ve), cough (+ve), catarrh (-ve) and malaria (+ve) significantly influenced children's medical expenses (p<0.10). It was recommended that subsidy for children malaria treatment, provision of more mosquito nets and awareness creation on preparedness of households for adverse climatic situations. [A.S. Oyekale and Y.A. Adesanya. Climate Change and Urban Children's Health: A Case Study of Ibadan South West Local Government, Nigeria. Life Sci J 2012; 9(3):894-899]. (ISSN: 1097-8135). http://www.lifesciencesite.com.127