Coping with climate change in agriculture requires knowledge of trends in agro-climatic conditions with a focus at the smaller scales where decisions are taken. As part of the EU FP7 ACQWA project, the situation was analyzed for agriculture in the case of the Swiss Rhone catchment (Valais) where cultivation of permanent crops (orchards and vineyards) and livestock production are the most important agro-economic activities. The aim of this study was to use daily data from four downscaled and bias corrected transient climate change scenarios to analyze changes in water and temperature related indices over the period 1951-2050 for three locations (Aigle, Sion, Montana) that are representative of different production zones in the catchment. The results indicate that most relevant implications are caused by projected changes in temperature and not in precipitation. They indicate an extension of the thermal growing season with potentially positive effects on pasture and livestock production, most pronounced at the mountain site (Montana), but a trend towards increasing risks of frost in permanent crops and in heat stress for livestock at the valley bottom (Aigle, Sion). The increase in water requirement for irrigation in 2021-2050 relative to 1981-2009 is moderate (4-16%, depending on location). However, in years with low amounts of snow and rain, in small catchments with a nival regime, reduced water supply by rivers could restrict the surface area of grassland that can be irrigated, particularly during springtime. It is concluded that coping with heat-related risks may be most needed at the lower cropland and pasture sites while water-related issues would become more relevant in more elevated locations where pasture-based livestock production is the dominant type of agricultural land use.