Precipitation extremes are increasing globally due to anthropogenic climate change. However, there remains uncertainty regarding impacts upon flood occurrence and subsequent population exposure. Here, we quantify changes in population exposure to flood hazard across the contiguous United States. We combine simulations from a climate model large ensemble and a high-resolution hydrodynamic flood model-allowing us to directly assess changes across a wide range of extreme precipitation magnitudes and accumulation timescales. We report a mean increase in the 100-year precipitation event of similar to 20% (magnitude) and >200% (frequency) in a high warming scenario, yielding a similar to 30-127% increase in population exposure. We further find a nonlinear increase for the most intense precipitation events-suggesting accelerating societal impacts from historically rare or unprecedented precipitation events in the 21st century. Plain Language Summary Heavy rainfall is increasing globally due to human-caused global warming. However, it is still unclear how these increases in heavy rainfall might affect flood risk. In this paper, we investigate how global warming and population changes together may be affecting the number of people at risk from floods in the United States. We combine simulations from a climate model and flood model-allowing us to consider a wide range of heavy rainfall events. We report a similar to 20% increase in the size and a >200% increase in the frequency of very heavy and rare rainfall events, which leads to a similar to 30-127% increase in the number of people at risk from floods. Finally, we find that the heaviest rainfall events increase by the widest margin-suggesting the possibility of major increases in damage and disruption caused by severe floods in the 21st century.