In the USA, many agencies take a One Health approach to understanding and managing the interconnected social, environmental and animal determinants of health. NOAA is a diverse agency that includes weather forecasting, climate data and service provision, fisheries management, and ocean and coastal management. Its One Health coordination team acts as a forum to raise and collaborate on intersectional health topics ranging from marine mammal disease, harmful algal blooms, extreme heat impacts, air quality and the environmental factors influencing vector-borne diseases. It also serves as a single point of entry for requests from partners in government (Centers for Disease Control and Prevention (CDC), Department of Homeland Security, Department of State and so forth) and non-governmental stakeholders and partners. The One Health team meets monthly, but also collaborates through a variety of other agency and multi-agency fora. For example, the National Integrated Heat Health Information System (NIHHIS), which is led by NOAA and CDC, but inclusive of many other agencies, hosts several different inter-agency working groups that have addressed heat season messaging, technical guidance for exertional heat exposure, and most recently, developed and launched Heat.gov to serve as the United States Government’s integrated resource for heat and health information. Through the One Health team at NOAA, NIHHIS can address the issue of heat, considering the downstream impacts of extreme heat on human, animal and environmental health. NOAA’s One Health team also provides climate expertise to the United States federal Interagency Crosscutting Group on Climate Change and Human Health (CCHHG). Co-led by NOAA, CDC and the National Institute of Health (NIH), it helps align 14 agencies across the United States federal government and coordinates, implements, evaluates and communicates federal research and scientific activities related to the human health impacts of global climate change. The CCHHG has enabled the first Climate and Health Assessment (CHA) to synthesize the state of the science around climate impacts to health in the USA. The CHA informs public health officials, decision makers and other stakeholders.