INTRODUCTION: It has been demonstrated that weather conditions have significant impacts on freeway safety. However, when employing an econometric model to examine freeway crash injury severity, most of the existing studies tend to categorize several different adverse weather conditions such as rainy, snowy, and windy conditions into one category, "adverse weather," which might lead to a large amount of information loss and estimation bias. Hence, to overcome this issue, real-time weather data, the value of meteorological elements when crashes occurred, are incorporated into the dataset for freeway crash injury analysis in this study. METHODS: Due to the possible existence of spatial correlations in freeway crash injury data, this study presents a new method, the spatial multinomial logit (SMNL) model, to consider the spatial effects in the framework of the multinomial logit (MNL) model. In the SMNL model, the Gaussian conditional autoregressive (CAR) prior is adopted to capture the spatial correlation. In this study, the model results of the SMNL model are compared with the model results of the traditional multinomial logit (MNL) model. In addition, Bayesian inference is adopted to estimate the parameters of these two models. RESULT: The result of the SMNL model shows the significance of the spatial terms, which demonstrates the existence of spatial correlation. In addition, the SMNL model has a better model fitting ability than the MNL model. Through the parameter estimate results, risk factors such as vertical grade, visibility, emergency medical services (EMS) response time, and vehicle type have significant effects on freeway injury severity. Practical Application: According to the results, corresponding countermeasures for freeway roadway design, traffic management, and vehicle design are proposed to improve freeway safety. For example, steep slopes should be avoided if possible, and in-lane rumble strips should be recommended for steep down-slope segments. Besides, traffic volume proportion of large vehicles should be limited when the wind speed exceeds a certain grade.