Flooding is one of the most destructive climatic hazards which has affected agricultural activities in the world, especially Sub-Saharan Africa. This article investigated the impact of the recurrent annual floods on food production and how subsistent farmers have adapted to resultant food insecurity in the Sudan Savannah agroecological zone of Ghana. The specific objectives of the study were to understand the nature of flooding (frequency, period and extent of coverage of flood water), how the perennial floods contribute to food insecurity, how farmers adapt to it to contribute towards policy development on flood control and improve food security. Primary data were collected using questionnaires, interviews, focus group discussions and field observation. Secondary data were obtained from documents and reports from NADMO and MOFA. The questionnaires were analyzed using Statistical Package for Social Science and the focus group discussions, interviews, and fieldwork were analyzed manually using content analysis. The findings show that the study areas experience floods every year. Between 2007 and 2018, eleven floods event occurred in the study communities. The floods usually occur around August and September when rainfall is torrential coupled with overflow from the spillage of the Bagre dam upstream. The flooding has resulted in a decline in food production among subsistent farmers. As a result, households in study communities are food insecure. Farmers have learned to cope with floods/food insecurity by engaging in alternative livelihoods such as flood recession farming, dry season farming, petty trading. They have also employed other means such as rationings of food and social networks cope with food insecurity. In all these strategies, women play a critical role as they are largely in charge of food preparation and dishing. The study recommends strengthening of the alternative livelihoods, introduction of short maturing crop varieties, sensitisation of women on the preparation of healthy meals.