Four pollution related diseases, namely asthma, conjunctivitis, URTI and dengue will be studied in terms of their trend, behaviour and association with influential factors such as air pollution and climate variables. Two methods were chosen; Poisson Generalized Linear Model and Negative Binomial Model. These methods were used to determine the association between the diseases and their influential factors. This study shows that Sulphur Dioxide (SO2) is the most abundant source that contributes to the diseases. Therefore, the local authorities such as the Department of Environment need to reinforce the law in planning and monitoring the SO2 sources which are produced from fuel combustion in mobile sources and motor vehicles.