Climate change and air pollution have been a matter of serious concern all over the world in the last few decades. The present review has been carried out in this concern over the Indian cities with significant impacts of both the climate change and air pollution on human health. The expanding urban areas with extreme climate events (high rainfall, extreme temperature, floods, and droughts) are posing human health risks. The intensified heat waves as a result of climate change have led to the elevation in temperature levels causing thermal discomfort and several health issues to urban residents. The study also covers the increasing air pollution levels above the prescribed standards for most of the Indian megacities. The aerosols and PM concentrations have been explored and hazardous health impacts of particles that are inhaled by humans and enter the respiratory system have also been discussed. The air quality during COVID-2019 lockdown in Indian cities with its health impacts has also been reviewed. Finally, the correlation between climate change, air pollution, and urbanizations has been presented as air pollutants (such as aerosols) affect the climate of Earth both directly (by absorption and scattering) and indirectly (by altering the cloud properties and radiation transfer processes). So, the present review will serve as a baseline data for policy makers in analyzing vulnerable regions and implementing mitigation plans for tackling air pollution. The adaptation and mitigation measures can be taken based on the review in Indian cities to reciprocate human health impacts by regular air pollution monitoring and addressing climate change as well.