The increased interest and investment in climate change and health research and policy should be a turning point for providing policy-relevant projections of how changing weather patterns and climate trends could alter the magnitude and distribution of climate-sensitive health outcomes. Decision makers recognise that future health burdens result from interactions between exposure, sensitivity, and the capacity to adapt. Fit-for-purpose projections to inform climate risk management should be based on a range of scenarios of greenhouse gas emissions and socioeconomic development. The relevance, use, and robustness of projections would be improved by addressing the considerations outlined here.