The Strategic Framework focuses on EID at the animal–human–ecosystems interface, where there is the potential for epidemics and pandemics that could result in wideranging impacts at the country, regional and international levels. The objectives and outputs of the Strategic Framework focus on some of the major drivers for emergence, spread and persistence of EID. The approach pursued in the Strategic Framework builds on lessons learned from the response to ongoing HPAI H5N1 infections. The objective of the Framework is to establish how best to diminish the risk and minimize the global impact of epidemics and pandemics due to EID, by enhancing disease intelligence, surveillance and emergency response systems at national, regional and international levels, and by supporting them through strong and stable public and animal health services and effective national communication strategies. National authorities play a key role in devising, financing and implementing these interventions. Successful implementation will contribute significantly to the overall goal of improving public health, food safety and security, and the livelihoods of poor farming communities, as well as protecting the health of ecosystems.