The ECOMORE II project developed a climate-based tool dengue leptospirosis to identify risks of these diseases across Southeast Asia, including Cambodia, Laos, Vietnam, Myanmar, and the Philippines. The tool integrates climate data—such as temperature, rainfall, and humidity—with epidemiological surveillance to anticipate outbreaks and guide early responses. By providing forecasts based on shifting environmental conditions, it helps health authorities target interventions, allocate resources efficiently, and reduce health impacts. This integrated, multisectoral approach strengthens proactive prevention against climate-sensitive, vector-borne diseases. The case study offers a scalable model for climate-informed surveillance and adaptive public health strategies across the region.