Fiji is prone to climate change hazards including sea-level rise, cyclones and floods, with increases in extreme weather events, such as shifting wet/dry seasons and extreme rainfall days, likely in the coming decades. These changes are expected to influence disease patterns, community resilience and health systems. Fiji is already experiencing a rapidly growing health burden due to the increased incidence and prevalence of non-communicable and communicable diseases, combined with increasing climate change-related health impacts. In the absence of appropriate and rapid health-focused adaptation strategies, climate change has the potential to cause a range of significant negative health impacts. In Fiji climate change affects human health through multiple pathways, including increased risk of waterborne diseases (such as diarrheal diseases) and vector-borne diseases (such as dengue), increased food and water insecurity leading to nutritional issues, and disruption of health systems due to climate-induced extreme weather events and sea-level rise. The combination of exposure to climatic hazards with limited capacity of the health system, including inadequate infrastructure, human resources and supplies, as well as communities that are remote and hard to reach, provide significant challenges in reducing climate change-related morbidity and mortality.