Existing frameworks for interpreting and acting upon the health consequences of climate change fail to engage with the multiple and complex forms of loss and damage that Indigenous peoples experience to their health and wellbeing in a changing climate. Using a case study of Maori in Aotearoa New Zealand, we call for a new research agenda that foregrounds Indigenous peoples' collective, relational perspectives on health and wellbeing in order to better conceptualise the health implications of climate change. The agenda builds understanding and recognition of intangible loss and damages, bringing multiple knowledge systems and worldviews into conversation to drive adaptation that not only safeguards but also promotes the visions Indigenous peoples have for their health and wellbeing.