With the effects of climate change, people are increasingly facing human-perceived heat stress (HPHS), which describes the combined effects of high temperature, high humidity, and low surface wind speed. HPHS has a significant impact on industrial and agricultural production, people's lifestyles, and public health. However, the characteristics of HPHS with respect to changes and influencing factors have not been fully investigated using dynamic classification of urban, suburban, and rural stations based on absolute and relative thresholds of seven HPHS indices in Southwest China. The results of this study revealed that, first, during the period 1961-2019, the normal annual and seasonal HPHS values and extreme HPHS days increased significantly, while the extreme HPHS values for the seven HPHS indices decreased. Second, based on the absolute and relative thresholds, the frequency and intensity of the impact of urbanization differed in four regions, and in Yunnan and Guizhou in particular. Different HPHS indices and different dynamic station classification methods result in different esti -mations of the effects of urbanization on annual and seasonal changes in the regional climate. Therefore, choosing an appropriate dynamic station classification method and considering the applicability of different indices in different seasons in different regions is very important. Third, the Granger causality test shows that the percentage of stations with Granger causality between landscape composition indices and seven extreme HPHS is the highest among all influencing factors. At the same time, boosted regression tree detection also showed that the landscape composition indices had the highest contribution percentage to the seven extreme HPHS. There-fore, rational planning of land-use patterns, especially in relation to urban forest land, grassland, wetland, and water bodies (including vertical landscape composition, configuration planning, and building density and layout) has implications for the realization of the United Nations Sustainable Development Goals (SDGs), in particular SDG 11, Sustainable Cities and Communities.