Non-economic loss and damage induced by climate change in the Pacific Islands region has been reported as fears of cultural loss, deterioration of vital ecosystem services, and dislocation from ancestral lands, among others. This paper undertakes an in-depth systematic review of literature from the frontlines of the Pacific Islands to ascertain the complexities of non-economic loss and damage from climate change. We synthesise knowledge to date on different but inter-connected categories of non-economic loss and damage, namely: human mobility and territory, cultural heritage and Indigenous knowledge, life and health, biodiversity and ecosystem services, and sense of place and social cohesion. Identifying gaps and possibilities for future research agendas is presented. Synthesising knowledge to date and identifying remaining gaps about non-economic loss and damage is an important step in taking stock of what we already know and fostering action and support for addressing loss and damage in the years to come.