It is well established that socioeconomic development processes often result in alterations of ecosystems with significant consequences on human health. The health and environment sectors are often left to mitigate such consequences with limited financial resources and at their own cost. The Libreville Declaration on Health and Environment in Africa is the main policy framework for addressing health and environment challenges coherently. To date, countries have set their health and environment priorities and some have prepared their national plans of joint action. It is now time to scale up investments for their implementation. This Framework aims at stimulating government investments in large-scale health and environment development projects or programmes with a potential impact on socioeconomic development. The Framework promotes the strengthening and institutionalization of country task teams for implementing the Libreville Declaration, the identification and selection of best practices and locally appropriate standards in the services and interventions offered to local communities, the development of funding proposals that are directly linked to national development objectives and the appropriate use of existing funding opportunities.