The study of the impacts and drivers of climate change adaptation should consider gender (in)equality and women's participation, as they both play pivotal roles. However, research on gender aspects of climate change adaptation has been limited. This study assesses gender dimensions of adaptation to climate change and de-terminants of smallholder farmers' adaptation strategies in Adwa district, Tigray, Ethiopia. Drawing on house-hold surveys, key informant interviews, and focus group discussions carried out in 2017, the study found that climate change had more severe impacts on female-headed households than on male-headed households. This was due to women's lack of resource access and control, lack of income and technology use, and high depen-dence on natural resources. Major climate change adaptation measures identified in the study area included adjustment of planting dates, crop varieties, water harvesting practices, soil and water conservation, irrigation, seasonal migration, diversifying income sources, and agricultural inputs. Rates and extent of adaptation varied by gender. As indicated by multivariate probit analysis, major determinants of farmers' adaptation choices included agro-ecology; gender, age, education, family size, farm size, non-farm income, livestock; access to in-formation, extension services, and credit; and distance to market center. Study findings suggest that policy-makers should consider differences between female-and male-headed families in their access to land, information, income, extension services, technologies, and other resources. By doing so, climate change adap-tation practices may be broadened and sustainable development promoted.