This case study provides an overview of the active heat health collaborations, projects and research ongoing in Hong Kong and presented during the First Global Forum on Heat and Health. Hong Kong faces unique challenges from environmental hazards, such as climate change and variability, due to its densely populated and almost entirely urbanized living environment. An increased vulnerability to the urban heat island effect means that its inhabitants are more susceptible to the harmful, and sometimes deadly, health effects of extreme heat. This case study exemplifies how a multidisciplinary partners and agencies are collaborating to protect the most vulnerable communities.