This study aims to assess watershed-scale impacts of changing climate on sediment, phosphorus, nitrogen and pesticide (atrazine) fluxes over the 21st century at the watershed scale. In particular, changes in dissolved and particulate forms of water quality constituents in response to climate change are investigated. The hydrologic model Soil and Water Assessment Tool was calibrated and evaluated in a primarily agricultural watershed in the Midwestern United States to simulate hydrologic and water quality processes on a daily basis over the 2015-2099 time horizon. The model was then driven with 112 distinct statistically downscaled climate projections representing Intergovernmental Panel on Climate Change Special Report on Emissions Scenarios (IPCC SRES) low, moderate and high greenhouse gas emission scenarios. Projected hydrologic and water quality responses were categorized according to the three IPCC SRES emission scenarios for summarizing and synthesizing results over early-century (2015-2034), mid-century (2045-2064) and late-century (2080-2099) assessment. Results revealed clear warming trends in the study area, whereas small increases in precipitation were predicted. Streamflow, sediment and total nutrient loads did not differ noticeably between assessment periods. However, the proportion of dissolved to total nutrients increased significantly from early-century to late-century periods. With the exception of total atrazine in the mid-century period, predicted pollutant loads for a given assessment period did not differ between emission pathways for a given assessment period. Changes in pollutant fluxes showed pronounced monthly variability. The projected increase in readily available forms of nutrients has important implications for the ecological health of water systems and management of drinking water supplies. Copyright (c) 2013 John Wiley & Sons, Ltd.