Climate change presents a significant threat to reducing the burden of malaria globally and in Sub-Saharan Africa, which, despite tremendous progress, continues to have a devastating impact on human health and livelihood throughout the world. Changes in temperature, precipitation and in the frequency and intensity of extreme weather events will alter the nature of malaria and other water- and vector-borne diseases, placing more people at risk of exposure. In Ethiopia, malaria poses a unique challenge for the government, which is working tirelessly toward malaria elimination. Increased temperatures are shifting malaria incidence to the highlands and to communities that have previously had very limited exposure to the disease.