West Nile fever (WNF) is the most important mosquito-borne disease in several countries of Europe. The annual phenology of the infection is mainly influenced by the seasonal activity of mosquitoes and humans. Culicid mosquitoes, the main vectors of West Nile virus prefer humid and warm conditions. This study was aimed at analyzing the West Nile fever season in Greece, Hungary, Israel and the Palestinian territories, Italy, Romania, and Serbia comparing the effect of ambient temperatures and precipitation sums on the case number of the disease. The countries were divided into two main groups Mediterranean and continental based on their climate. Epidemiological data of the European Centre for Disease Prevention and Control and climatic data of the European Climate Assessment and Dataset were used in the analysis. In each of the studied countries, positive correlations (0.202