The relative contributions of PM(2.5) and ozone precursor emissions to air pollution-related premature mortality modulated by climate change are estimated for the U.S. using sensitivities of air pollutants to precursor emissions and health outcomes for 2001 and 2050. Result suggests that states with high emission rates and significant premature mortality increases induced by PM(2.5) will substantially benefit in the future from SO(2), anthropogenic NO(X) and NH(3) emissions reductions while states with premature mortality increases induced by O(3) will benefit mainly from anthropogenic NO(X) emissions reduction. Much of the increase in premature mortality expected from climate change-induced pollutant increases can be offset by targeting a specific precursor emission in most states based on the modeling approach followed here.