Water is essential for economic, social, and environmental development. Global water resources are vulnerable due to increasing demand related to population growth, pollution potential, and climate change. Competition for water between different sectors is increasing. To meet the increasing demand, the use of groundwater is increasing worldwide. In this paper, the water-table dynamics of the north-eastern region of Bangladesh were studied using the MEKESENS software. This study reveals that the depth to water-table (WT) of almost all the wells is declining slowly. In many cases, the depth will approximately double by the year 2040, and almost all will double by 2060, if the present trend continues. If the decline of the water-table is allowed to continue in the long run, the result could be a serious threat to the ecology and to the sustainability of food production, which is vital for the nation's food security. Therefore, necessary measures should be taken to sustain water resources and thereby agricultural production. Demand-side management of water and the development of alternative surface water sources seem to be viable strategies for the area. These strategies could be employed to reduce pressure on groundwater and thus maintain the sustainability of the resource.