The interdisciplinary study of oceans and human health is an area of increasing global importance. There is a growing body of evidence that the health of the oceans and that of humans are inextricably linked and that how we interact with and affect our oceans and seas will significantly influence our future on earth. Since the emergence of modern humans, the oceans have served as a source of culture, livelihood, expansion, trade, food, and other resources. However, the rapidly rising global population and the continuing alterations of the coastal environment are placing greater pressure on coastal seas and oceans. Negative human impacts, including pollution (chemical, microbial, material), habitat destruction (e.g., bottom trawling, dredging), and overfishing, affect not only ecosystem health, but also human health. Conversely, there is potential to promote human health and well-being through sustainable interactions with the coasts and oceans, such as the restoration and preservation of coastal and marine ecosystems. The study of oceans and human health is inherently interdisciplinary, bringing together the natural and social sciences as well as diverse stakeholder communities (including fishers, recreational users, private enterprise, and policymakers). Reviewing history and policy with regard to oceans and human health, in addition to known and potential risks and benefits, provides insights into new areas and avenues of global cooperation, with the possibility for collaboratively addressing the local and global challenges of our interactions with the oceans, both now and in the future.