Coastal and riverine communities in the United States are largely unprepared for the projected effects of the climate crisis, including more intense storm surges, sea level rise, and increased precipitation. Flooding poses its own hazards, but in recent years, chemical releases triggered by extreme weather, such as hurricanes, have become more frequent, exposing nearby communities to toxic chemicals in the midst of natural disaster. This article reviews the public health implications of chemical releases triggered by extreme weather and provides commentary on possible policy solutions. The Gulf Coast, where there is an abundance of chemical facilities, is particularly vulnerable to these events, one of the latest examples being the August 2020 BioLab chlorine factory fire in Lake Charles, Louisiana, during Hurricane Laura. Low-wealth, Black, and Hispanic communities are disproportionately located near high-risk chemical facilities. The cumulative burden of flooding, toxic chemical releases, and other social stressors borne of systemic racism harms these communities, highlighting a critical environmental injustice. The federal and state governments have failed to develop regulatory safeguards that would prevent chemical releases triggered by extreme storms. State regulators should make facility reporting data available to the public and establish a regulatory regime for aboveground storage tanks. State regulators should also complete an analysis of flood risks to high-risk chemical facilities and impacts on historically disenfranchised communities, require permitted facilities to implement climate-responsive spill preventions practices, and establish a task force that can investigate strategies to prevent climate-driven chemical disaster and engage key stakeholders.