This public health research agenda for infodemic management was developed by WHO. The aim is to foster a coordinated and evidence-based approach to ensure universal access to reliable health information. WHO convened more than 100 experts from 20 disciplines across more than 30 countries online from June through October 2020 to identify priority research questions for this emerging discipline. The research agenda comprises five focus areas or “streams” for accelerated action. These streams span the evaluation of infodemic impacts, how to study them, what drives them, approaches to better manage them, and considerations for operationalizing new tools for both the science and practice of infodemic management. This agenda may serve as a reference point for WHO, partners, research agencies, and academia towards building global capacity for better managing present and future health threats.