Several vector-borne diseases, such as malaria, are sensitive to climate and weather conditions. When unusual conditions prevail, for example, during periods of heavy rainfall, mosquito populations can multiply and trigger epidemics. This study, which consists of better understanding the link between malaria transmission and climate factors at a national level, aims to validate the VECTRI model (VECtor borne disease community model of ICTP, TRIeste) in Senegal. The VECTRI model is a grid-distributed dynamical model that couples a biological model for the vector and parasite life cycles to a simple compartmental Susceptible-Exposed-Infectious-Recovered (SEIR) representation of the disease progression in the human host. In this study, a VECTRI model driven by reanalysis data (ERA-5) was used to simulate malaria parameters, such as the entomological inoculation rate (EIR) in Senegal. In addition to the ERA5-Land daily reanalysis rainfall, other daily rainfall data come from different meteorological products, including the CPC Global Unified Gauge-Based Analysis of Daily Precipitation (CPC for Climate Prediction Center), satellite data from the African Rainfall Climatology 2.0 (ARC2), and the Climate Hazards InfraRed Precipitation with Station data (CHIRPS). Observed malaria data from the National Malaria Control Program in Senegal (PNLP/Programme National de Lutte contre le Paludisme au Senegal) and outputs from the climate data used in this study were compared. The findings highlight the unimodal shape of temporal malaria occurrence, and the seasonal malaria transmission contrast is closely linked to the latitudinal variation of the rainfall, showing a south-north gradient over Senegal. This study showed that the peak of malaria takes place from September to October, with a lag of about one month from the peak of rainfall in Senegal. There is an agreement between observations and simulations about decreasing malaria cases on time. These results indicate that the southern area of Senegal is at the highest risk of malaria spread outbreaks. The findings in the paper are expected to guide community-based early-warning systems and adaptation strategies in Senegal, which will feed into the national malaria prevention, response, and care strategies adapted to the needs of local communities.