Climate-related hazards such as heatwaves, flooding, wildfires, and storms will increase morbidity and mortality unless infrastructure decision-makers-including urban planners, infrastructure asset managers, and utility providers-implement preventive measures to protect public health from these hazards. Existing research and policies have not systematically identified the key risk factors that these decision-makers need to manage to protect public health in a changing climate. This gap leads to unclarity regarding what infrastructure interventions are required to prevent climate-related health risks and what actors have a responsibility to manage these risks. The Climate-Health-Infrastructure-Pathways Model is introduced in this paper to address this gap and provide a conceptual map that captures the role of physical infrastructure systems in the pathways between climate-related hazards and health risks. The model surpasses what can be found in existing climate change research and policy, including the latest IPCC reporting, and is a conceptual qualitative tool that offers a typology of climate and health risks for infrastructure management. Decision-makers can use the model as a starting point to review the coverage of their current climate risk management plans and identify further opportunities to develop preventive infrastructure responses to protect public health in a changing climate.