This study investigated impacts of climate variability on mosquito survival at Obafemi Awolowo University Campus, Ile-Ife, south-western Nigeria, and determined the regional climate suitability level for malaria transmission between 1996 and 2015. It employed some established climate-dependent models to simulate daily mosquito survival probabilities, p and a fuzzy logic suitability (FLS) model to determine the suitability conditions for malaria transmission across seasons. Multivariate regression analysis and lag correlation up to 4 months were performed to examine contributions of climate variation to the reported malaria cases. Results revealed that mosquitoes could survive all-year round with p values ranging between 0.40 and 0.96 under the prevailing mean climate. However, the climate suitability level for transmission of malaria was 'moderate' (0.45 < p