The guide provides practical information and concrete guidance for programme managers working in climate change and health adaptation to mainstream gender throughout all four phases of the project cycle. It covers topics such as conducting a gender analysis of health vulnerability and adverse health impacts of climate change, designing gender-responsive adaptation programmes and actions, and integrating gender considerations within health adaptation strategies. The guide is divided into three sections, covering the key terms and concepts of gender mainstreaming, the gender dimensions of climate change and health, and practical guidance and best practices for mainstreaming gender in health adaptation to climate change programmes. The recommendations provided in the guide can help programme managers effectively mainstream gender and improve health outcomes.