This guidance document outlines the process for conducting a climate change and health V&A assessment for diarrhoeal diseases. It describes the steps for: identifying populations and regions vulnerable to diarrhoeal diseases and the reasons for their vulnerability; establishing relevant baselines that can be analysed and monitored; conduct analyses to project how diarrhoeal diseases may be impacted in the future due to climate change; and identify appropriate responses to mitigate and monitor these risks over time.